A native of upstate New York, Derek Richardson began his career with a guest-starring role on Law & Order. Soon after moving to Los Angeles, Richardson landed a recurring role on Felicity as Keri Russell's love interest. He has guest starred on such shows as House, Psych and American Horror Story as Jessica Lange's attorney. Additionally, Richardson starred in Hostel, directed by Eli Roth and executive produced by Quentin Tarantino, as well as the ABC series Men in Trees with Anne Heche.

Richardson can currently be seen in FX's new comedy show Anger Management alongside Charlie Sheen.