Diane Lane stars as "Jennifer Brown," a top Democratic lawmaker who's polished public image hides a complicated family life. After a worldwide disaster wipes out every person with a Y chromosome, Jennifer moves up the line of succession to become President, a lifelong ambition under the worst possible circumstances. Jennifer assembles a dedicated team of women to rebuild the country, only to have her plans upended when she learns her son Yorick might be the sole survivor of the Event.